ARTERIOSCLEROSIS, ATHEROSCLEROSIS AND HYPERTENSION 

How to understand your disease of aging : ageless man

 AGELESS MAN   AMAZON 2017-2022

 

According to the "Vital Statistics Report" of the National Centre for Health Statistics, the cardiovascular diseases are the first cause of death in the world and in the United States (30).

The arteries are involved by two different phenomenon, arteriosclerosis and atherosclerosis, which occur often simultaneously.

The pathology of arteriosclerosis is characterized by the replacement of the muscular fibers of the artery by collagen tissue which is inelastic.

A similar pathology was described 50 years ago with the ureter under pressure.

The pathology of atherosclerosis is characterized by fat and cholesterol involvement of the arterial wall. This phenomenon is the consequence of cholesterol and lipid accumulation in the body through the impaired sugar and fat metabolism when testosterone is missing.

Arteriosclerosis and atherosclerosis are two general involution phenomenon increasing with the decrease of testosterone secretion. It is probably the reason for the elevation of blood pressure with age

 GANGRENE

GANGRENE

Gangrene of toes is sometimes the result of maturity onset diabetes. Testosterone treatment proposed  by Jens Moeller (6) gives spectacular results.

  

                                                                                    A                                                B

A . Man aged 55, with gangrene of the left 1st and 3rd toes for which amputation of the left leg had been advised. (6)

B.  The left foot before (A) and after 3 months of treatment with testosterone (6)

HYPER COAGULATION, VARIX, HEMORROIDES, THROMBOSIS, ANEMIA,

BLOOD HYPERCOAGULABILITY 

The main question about blood is not " how it coagulates" but "how it remains fluid". Thrombosis and embolism are common complications of cardiovascular diseases usually treated by

anticoagulant agents as heparin or dicoumarin. The use of those substances can produce hemorrhages.

The dissolution of the blood clot is under the influence of fibrinolysis agents.

Fibrinolitic agents of the blood are under the influence of testosterone as reported in the Lancet of the 21 July 1962 by Fearnley and coll. (2).

Claire Bonithon-Kopp and coll. from the Broussais hospital in Paris, who demonstrated in 1988 that low plasmatic levels of male hormone contributes to hypercoagulability and to ischemic heart disease (3).

BLOOD FLUIDITY 

Blood fluidity depends on antithrombin III which is a blood fluidizing factor that allows blood to flow. A normal amount of antithrombin III in plasma ensures optimal fluidity which depends on the available testosterone.

VARIX, HEMORROIDS AND THROMBOSIS 

Veins like arteries are constituted by muscular fibres. Loss of testosterone produces always an involution of their muscular tissue.

ANEMIA 

The number of red blood cells is  decreased from 10% in castrated men. This is often so in men with low testosterone plasmatic levels. The ischemic heart disease is of course aggravated by this phenomenon.

In 1981, Najean and coll. reported in the American Journal of Medicine the improvement of anemia in a serial of 137 patients when treated by male hormones. Anemia recurs when the therapy is stopped and improve again with androgens (4).

On the other hand, patients with polyglobulia may constitute a problem for therapy with androgens. The normal account of red blood cells varies normally (5,4 + 0,9 millions/milliliter) (5). So patients with 6,3 millions red blood cells/milliliter and presenting a failure in the life maintenance system can be carefully treated with an appropriate monitoring of the androgens without increasing of the number of their red blood cells. Those cases are rare.

Bibliography

1. NATIONAL CENTER FOR HEALTH STATISTICS .Vital Statistics Report, Final Mortality Statistics, 1982.

2. FEARNEY G.R. AND CHAKRABARTI R. Increase of Blood Fibrinolytic Activity by Testosterone :

The Lancet, July 21 : 128-132, 1962.

3. BONITHON-KOPP C., SCARABIN P.-Y., BARA L., CASTANIER M., JAQUESON A. AND ROGER M. Relationship between Sex Hormones and Haemostatic Factors in Healthy Middle-Aged Men : Artheriosclerosis, 71: 71-76, 1988.

4. NAJEAN Y. and coll. Long Term Follow-up in Patients with Aplastic Anemia. A study of 137 Androgen-Treated Patients Surviving more than Two Years :  Am. J. Med.,  71 : 543-551, 1981.

5. HARRISON T.R. Principes de Médecine Interne. :

Appendice A 10. Tableau A-XII.  Médecine-Sciences Flammarion, 1989. Paris.

6. MOELLER J. Cholesterol : 27  Springer-Verlag  Berlin  Heidelberg  New York  London  Paris  Tokyo 1987.