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Precise long term treatment of andropause disease with androgens stabilize the prostate.

  PSA (Prostatic Specific Antigen) is a protein secreted by the prostate glands situated in the prostatic musculature . Its rate in blood is lower than 4 ng (nanogram) per milliliter.

PSA is not specific of cancer prostate. A rise in the PSA is observed in the event of cancer (not always) but also in adenoma and in  prostate infection.

Prostate specific antigen (PSA) total and free

Approximately 70 % of  total serum PSA circulate bounded to blood's proteins and 30 % in free form.
 Tests allow, either the proportioning of the total PSA, or only its free fractions (free PSA) or the bounded  PSA. Example:
PSA total 4
PSA free 1

PSA total ng/ml 4
PSA bounded ng/ml 3
PSA free ng/ml 1
PSA free /PSA total 25 %

Total proportion of free PSA/total PSA should be normally in general above 15%

Prostate specific antigen (PSA) and adenoma of the prostate

The total rate of PSA and the rate of the free form of the PSA can increase in the event of benign hypertrophy.

In the first stages of the andropause disease the fall of the testosterone secretion causes the reduction of dihydrotestosterone's production. At the same time it can exist a hyper production of estradiol (female hormone) and disordered state of the prostate cells'  biology . These anomalies are detectable by the study of the global pool of the androgens. They can be corrected.

Prostate specific antigen and cancer of the prostate

The bound form of PSA increases in the event of cancer. Free/total proportions PSA drop. For example:

Total PSA 10 ng/ml and

Free PSA 1 ng/ml

Free PSA/Total PSA= 1/10=10%

In USA certain insurers  do not refund any detection of prostate cancer with PSA tests for preventive diagnosis..

The man after 50 years has abnormal cells (what does not want to say invasive cancer!) in its prostate glands. At 60 years 50% of men have  abnormal prostate cells. This rate reaches to 75% at 70 years and 100% at 90 years.

It is remarkable to note that the testosterone secretion decreases regularly after 50 years (and sometimes even before) causing consequently the fall of the production of dihydrotestostérone (since this one comes only from the transformation of testosterone) in parallellism to the abnormal transformation of the prostate cells   .

The normal prostate  cellss do not multiply abnormally with male hormones which do not modify the activity of their telomerases

The test of an isolated PSA is not very comprehensible. It should always be interpreted according to the study of the  pool of androgens. In this context it is possible to detect and determine the cancerous transformation or not.


History of andropause disease
Life maintenance system

A foundation of life maintenance system

Health in XXIst century
Andropause disease in short  (powerpoint) logo powerpoint