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 ANTI AGING SOLUTIONS FOR  WOMAN
 

 

Understanding diseases of aging: ageless woman

Errors in menopause treatment

ANDROGENS IN WOMAN

ORIGINS - DAILY PRODUCTION - MOLECULAR STRUCTURE

The technical term “androgen” includes true androgens such as testosterone and dihydrotestosterone (DHT) active on their receptors,

but also precursors of androgens such as the dehydroepiandrosterone (DHEA), dehydroepiandrosterone  sulfate (SDHEA), and A4-androstenedione,

as androgens’ metabolites among which androstanediol, androsterone and their glucuronides derivatives (which are the principal metabolites’ representatives).

 

ORIGINS OF ANDROGEN’S PRODUCTION IN WOMAN

 Androgens’ are produced daily:

  • In the ovaries

  • In the adrenals

· In peripheral tissues

and constitute the total androgens’ production.

With ageing the daily androgen’s production varies in those three pathways.

When the ovaries’ production of androgens decreases for one or another reason (ageing, oophorectomy, menopause) the total pool of androgens is diminished.

When the total daily production is sufficient they are no symptoms of androgens’ deficiencies. This explains why women don’t suffer from androgens’ deficiencies at the same age.

DAILY PRODUCTION OF ANDROGENS During the normal menstrual cycle

Testosterone and Estradiol productions in µg/day

during the normal menstrual cycle

 

Estradiol

Testosterone

Proliferative phase

40 200

Secretory phase

200 200

Before menopause normal woman produces each day 5 fold more testosterone than estradiol in the proliferative phase and the same quantity in the secretory phase (1)

 

Androgens’ precursors productions in µg/day

during the normal menstrual cycle

 

DHEA

DHEAS

Androstenedione

Proliferative phase

5.000 15.000 4.000

Secretory phase

5.000 15.000 4.000

  

                                Testosterone and dihydrotestosterone in woman

In woman plasma dihydrotestosterone represents almost 50 % of testosterone levels:

Woman before menopause :

Plasmatic hormonal concentrations in ng /ml

Testosterone

0,57 ± 0,19 ng/ml

Dihydrotestosterone (DHT)

0,27 ± 0,06 ng/ml

 

Testosterone Dihydrotestosterone and mesterolone MOLECULAR STRUCTURES


 

formule testosterone 175 x 129

 Testosterone

 

Androstanolone.svg

Dihydrotestosterone

 

Mesterolone

Mesterolone has the structure of testosterone with a methyl group on C1.

Depending from its molecular structure Mesterolone

 1) has properties similar to those of testosterone (see appendix chemical formula

  2) Depending from its molecular structure Mesterolone has properties similar to those of  dihydrotestosterone